Imaginemos que un nuevo f\u00e1rmaco alargara la esperanza de vida en un treinta por ciento, ya que ayudara a preservar la dureza de los huesos en la tercera edad, a mantenerse delgado, redujera espectacularmente los problemas cardiovasculares ligados al envejecimiento y tuviera un saludable efecto antioxidante y protector contra la luz ultravioleta y posiblemente contra bastantes tumores. En Espa\u00f1a, donde la esperanza de vida ronda los 85 a\u00f1os m\u00e1s o menos, esto significar\u00eda unos 35 a\u00f1os m\u00e1s. \u00bfCiencia ficci\u00f3n? Pues puede ser que no.
\nEn un reciente estudio publicado en la revista cient\u00edfica [\u00abCell\u00bb:http:\/\/www.cell.com\/], investigadores de la \u00abFacultad de Medicina de New Jersey\u00bb:http:\/\/www.umdnj.edu\/ han descubierto que la eliminaci\u00f3n en ratones de un solo gen, adenilato ciclasa AC5, produce todos estos efectos:<\/p>\n
\nMammalian models of longevity are related primarily to caloric restriction and alterations in metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 KO) and which are resistant to cardiac stress and have increased median lifespan of ∼30%. AC5 KO mice are protected from reduced bone density and susceptibility to fractures of aging. Old AC5 KO mice are also protected from aging-induced cardiomyopathy, e.g., hypertrophy, apoptosis, fibrosis, and reduced cardiac function.\n<\/p><\/blockquote>\n
Pero tal f\u00e1rmaco no va a ser tan f\u00e1cil de crear. Veremos si es la nueva piedra filosofal.
\nVer:
\n¤ \u00abType 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress\u00bb:http:\/\/www.cell.com\/content\/article\/abstract?uid=PIIS0092867407006770 (Cell)
\n¤ \u00abSingle gene deletion boosts lifespan\u00bb:http:\/\/www.nature.com\/news\/2007\/070723\/full\/070723-10.html (Nature News)<\/p>\n","protected":false},"excerpt":{"rendered":"Imaginemos que un nuevo f\u00e1rmaco alargara la esperanza de vida en un treinta por ciento, ya que ayudara a preservar la dureza de los huesos en la tercera edad, a mantenerse delgado, redujera espectacularmente los problemas cardiovasculares ligados al envejecimiento y tuviera un saludable efecto antioxidante y protector contra la luz ultravioleta y posiblemente contra… Leer m\u00e1s »35 a\u00f1os m\u00e1s<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[43],"tags":[601,600,214,598,599],"class_list":["post-931","post","type-post","status-publish","format-standard","hentry","category-ciencia","tag-ac5","tag-adenilato-ciclasa","tag-ciencia-2","tag-longevidad","tag-vida"],"_links":{"self":[{"href":"https:\/\/junjan.org\/wordpress\/wp-json\/wp\/v2\/posts\/931","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/junjan.org\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/junjan.org\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/junjan.org\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/junjan.org\/wordpress\/wp-json\/wp\/v2\/comments?post=931"}],"version-history":[{"count":1,"href":"https:\/\/junjan.org\/wordpress\/wp-json\/wp\/v2\/posts\/931\/revisions"}],"predecessor-version":[{"id":1276,"href":"https:\/\/junjan.org\/wordpress\/wp-json\/wp\/v2\/posts\/931\/revisions\/1276"}],"wp:attachment":[{"href":"https:\/\/junjan.org\/wordpress\/wp-json\/wp\/v2\/media?parent=931"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/junjan.org\/wordpress\/wp-json\/wp\/v2\/categories?post=931"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/junjan.org\/wordpress\/wp-json\/wp\/v2\/tags?post=931"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}